Key Immune-System Process For Cancer Treatments Discovered

first_imgBy Dialogo August 12, 2009 I visit this site and acquainted with this.This site publish most useful and valuable article. I read this post and find lot of things . I am really happy for reading and knowing this post. SEO Services Argentine scientists have discovered the mechanism that blocks the human immune system, a “key” to developing treatments for cancer, diabetes, and multiple sclerosis, official sources announced. The group of researchers, led by Gabriel Rabinovich, discovered “the molecular gears” that cause the immune system to deactivate itself and allow, for example, the expansion of tumorous cells, according to a statement issued by the National Council of Scientific and Technical Research (Conicet). The discovery is key to developing treatments for tumors or diseases like multiple sclerosis, arthritis, or diabetes, among others, which occur when the immune system activates itself without reason to do so and attacks the patient’s own tissues, the researchers explained. “This circuit that can turn off the defense system is known as ‘immunological tolerance.’ Building up tolerance is crucially important to avoiding the development of autoimmune diseases and promoting the acceptance of transplants,” Conicet noted. Dr. Rabinovich and his team discovered that in the presence of a protein (galectin-1), so-called dendritic cells become capable of turning off and shutting down the defense system. These cells acquire the name of “tolerance-inducing dendritic cells,” due to their ability to induce immunological tolerance during this process, in which two other proteins, interleukin-27 and interleukin-10, also play a role. The production of this last protein (interleukin-10) may finally suppress the defense system’s response both in autoimmune diseases and in infections and tumors. “In light of these results, it should be possible to look forward to new therapeutic horizons for various immune pathologies,” emphasized Rabinovich, a member of the faculty at the University of Buenos Aires, Argentina’s largest university. “Having identified a complete system of immune-response resolution allows us better understanding of the immune system and the possibility of manipulating it for our benefit,” added Juan Martín Ilarregui, another of the researchers. The study, published today by the British scientific journal Nature Immunology, began in 2003 with experiments using human and mouse cells. Specialists Diego Croci, Germán Bianco, Marta Toscano, Mariana Salatino, Jorge Geffner, Mónica Vermeulen, and Juan Stupirski also took part in the research.last_img read more

Colombia Chooses Woman as Chief Public Prosecutor

first_imgBy Dialogo December 03, 2010 The Colombian Supreme Court of Justice has chosen Viviane Morales as chief public prosecutor, ending a sixteenth-month vacancy due to a dispute between former president Alvaro Uribe and the judicial branch that delayed court cases and criminal investigations. This is the first time in the history of the South American country that a woman has been chosen as chief public prosecutor. Morales obtained fourteen out of eighteen votes cast by the justices who participated in the election. “After so long a vacancy, with so many tasks to carry out, with so many extremely delicate investigations that the public prosecutor has to deal with, the truth is that it’s a challenge that will mean working intensely, sacrificing my family life and personal life,” the new chief public prosecutor said. Morales promised a frontal assault on corruption and guaranteed independence and transparency at the head of the investigative agency.last_img read more

Panama Dismantles Group that Transported Drugs for FARC

first_img The Panamanian authorities dismantled a criminal gang that was allegedly responsible for the “transport of illicit substances” to Central America for the Colombian Revolutionary Armed Forces of Colombia (FARC), the Public Prosecutor’s Office announced on September 7. “Up to the present, we have 80 individuals in detention, against the majority of whom we already have investigation orders,” drug prosecutor Javier Caraballo said about the arrests, made on September 5. The detentions primarily took place in the Caribbean province of Colon and in the city of La Chorrera, 30 km west of the capital, where the police conducted some thirty searches as part of investigations begun two years ago, Caraballo said at a press conference. “What we can say on a preliminary basis is that this group was doing transport of illicit substances for groups like the FARC”, a leftist Colombian guerrilla organization. According to the prosecutor, the detainees provided “logistical support,” “transporting the illicit substances belonging to these organizations from Colombia to Central America.” He said that in these operations, 80 suspects were detained, 19 of them Colombians and the rest Panamanians, who were also allegedly linked to 18 tons of cocaine seized by the Panamanian authorities in the last two years. The gang was led by the Colombian José Indalecio Marmolejo Parra, who has been living in Panama for years under the false identity of Samuel Parra García, Caraballo said. Marmolejo had escaped from Colombia to Costa Rica after been linked to drug trafficking and arms trafficking for a group led by the late drug trafficker Pablo Escobar, according to the Panamanian prosecutor. “In this operation, at least 95 percent of the targets (suspects sought) were arrested,” the director of the Panamanian Police, Gustavo Pérez, affirmed. In the operation, 162 kilos of cocaine, several cars, and cash were also seized, the officials said. By Dialogo September 08, 2011last_img read more

Brazil: Phone Tips Result in 40,000 Arrests

first_imgBy Dialogo April 01, 2012 Since 2003, Brazilian military police have received more than 230,000 calls to their hotline in the state of Paraná, along the border with Argentina and Paraguay. The calls from citizens have led to the seizure of 8,000 kilos of cocaine and 10,000 crack rocks. Due to the program’s success, the federal government turned the state hotline into a national hotline with the states of Santa Catarina, Mato Grosso, São Paulo and Rio de Janeiro being the first to adopt the program. “Our objective is to integrate all the Brazilian states and to create a national database,” said Lieutenant Edivan Fragoso, coordinator of the military police narcotrafficking hotline. Source: www.infosurhoy.comlast_img read more

Colombian Navy’s International Maritime Center against Drug Trafficking: A Strategic Anti-Drug Solution

first_imgBy Julieta Pelcastre/Diálogo September 12, 2016 Since its founding on July 3rd, 2015, the Colombian Navy’s International Maritime Center Against Drug Trafficking (CIMCON for its Spanish acronym)), a leading research center on drug trafficking, has become an answer against criminal groups operating in the territorial waters of the Americas. After a year of work that created a “virtuous cycle” by combining the use of information with experience, academic research, information transfer, and case studies, CIMCON has finalized new operational recommendations and approaches to its regional security strategy for combating drugs, the Colombian Navy reported. “According to Colombian sources, an estimated 6 million nautical miles [11 million square kilometers] comprise the transit zone is used for illegal drug trafficking in the Caribbean and Central America. Over 50 percent of the drugs transported by sea transits or crosses through Colombian maritime jurisdiction,” Commander George Rincón, CIMCON director, told Diálogo. “No Navy has the capacity to exercise control in such a wide area. Regional navy integration is fundamental so that information flow can be more effective in operations at sea.” Fulfilling responsibilities CIMCON is located at the Admiral Padilla Barrio Bosque Naval Academy of Cadets facilities, in the city of Cartagena, Colombia. It was built with help from the United States government and has fulfilled its regional commitments: promoting closer ties among the countries affected by drug trafficking as well as studying drug trafficking and the evolution of the crime that affects all countries equally, according to the Colombian Navy. CIMCON has hosted experts from all over the Americas to develop the required studies and to fulfill the center’s proposed objectives. Since March 1, 2016, Captain Alfredo Ramón Enriquez Delgado was commissioned as researcher and Mexican Navy representative to CIMCON. For the past seven years, he has developed naval intelligence work. “Accumulated experience is very important. Capt. Enriquez has focused his efforts on studying submersibles and semi-submersibles because the use of this type of vessel is also a threat in Mexico. He ([Capt. Enriquez]) is participating in the analysis we’re doing on what is going on in the Pacific, the Caribbean and Central America with respect to the use of different dynamics and means of transportation used by drug-trafficking groups,” said Cmdr. Rincón. The results Over the past 23 years, Colombian authorities have confiscated 91 semi-submersibles that were going to be used for trafficking drugs from Colombia to the United States or Mexico. This vessel is an illegal marine vehicle handcrafted for trafficking drugs. Its construction requires materials, technology and a specialized workforce, which costs between $ 1 million and $ 1.5 million, according to Colombian daily El Tiempo. Since the beginning of the 90s, manufacturing techniques for the so-called “narco-submarines” have been improving, increasing their carrying capacity. They are currently able to smuggle up to 15 metric tons of drugs. Some vessels are silent and unmanned, while others are equipped with valves that allow them to fill up with water and submerge themselves in order to evade authorities. Honduras was the first Latin American country to send a researcher to the International Maritime Center Against Drug Trafficking. For six months, Honduran Navy Lieutenant Junior Grade Marlon Flores Ávila developed work related to Fusion Centers, a strategy applied to the region by the Colombian Navy since 2014. This strategy is known as a naval network, which is the sum of efforts, capacities and information. The strategy seeks to create “sanctuaries” where danger zones for drug trafficking organizations are created through national-level information exchange between the various Forces and Latin American agencies, Navies and Coast Guards; and through the implementation of Fusion Centers, which help coordinate information and anti-drug trafficking operations in real time, explained Commander Néstor O. Castellanos Zambrano, head of the Analysis and Operational Innovation Division of the Colombian Navy’s Direction Against Drugs, according to the website of the Maritime League of Colombia. “Using naval intelligence, Lt. Flores was able to compile important information that allowed him to develop the research work that he brought to his country. Honduras is seeing how to implement a Fusion Center; these centers have worked very well in Colombia,” explained Cmdr. Rincón. “What they are seeking to do is plant a seed, to try to make the International Maritime Center available to countries to hit hard at organizations on the margins of the law. We also hope to have United States researchers and analysts in the near future. France responded to the strategy and sent a couple of researchers to CIMCON.” Colombian naval intelligence and Honduran naval intelligence have become closer through CIMCON, allowing for the confiscation of over 3 metric tons of cocaine off the coast of Honduras in 2015. The drug seizures were carried out in various areas in Honduras, mainly in the sector of La Mosquita, in the department of Gracias a Dios. The future of CIMCON CIMCON is working on two proposals: the Fusion Centers and legal issues — developing legal seminars in the region, which allow for the standardization of procedures. The two proposals will be presented at the XV meeting of the group of experts of the Inter-American Drug Abuse Control Commission on maritime drug trafficking. The goal of the meeting, which will be held from September 13th to 15th in Cartagena, Colombia, is to strengthen the fight against drugs at the hemispheric level. “The Colombian Navy and the navies of the region are accustomed to developing naval intelligence. The navies have their place, and they are very effective, but the problem of drug trafficking is not being impacted — the problem persists. From an academic perspective, CIMCON, in its research and analysis role, is more about strategy than tactics, and we want to develop operational recommendations that contribute in some way, but that have a lot more impact on the problem of drug trafficking,” concluded Cmdr. Rincón.last_img read more

International Community Shows Brotherhood to Mexico

first_imgBy Julieta Pelcastre/Diálogo October 18, 2017 In September 2017, Mexico dealt with two large-scale earthquakes in less than 15 days. The first, with a magnitude of 8.3 on the Richter scale, struck on September 7th, leaving 100 dead in the southeast of Mexico. The second quake, on September 19th, with a magnitude 7.1, led to 320 fatalities and massive material losses in the nation’s center. In the face of the disaster, the international community immediately showed its support for Mexico. The Mexican government accepted aid from various countries and from every region of the world in order to assist the population affected by the second earthquake, which shook the states of Guerrero, Mexico, Morelos, Puebla, and Mexico City. “As Mexicans, we are moved by the countless demonstrations of immediate solidarity from the international community,” said Foreign Relations Secretary Luis Videgaray. Highly specialized aid and heavy machinery needed for mounting a quick response was brought in on military and commercial planes from 23 nations around the world. From the outset of the search-and-rescue operations, Mexico had technical support from the United Nations (UN) Office for the Coordination of Humanitarian Affairs. Their teams are part of the UN’s Disaster Assessment and Coordination, which identified the specific assistance that Mexico needed in order to support its search-and-rescue efforts. The outpouring of support reached Mexico in coordination with its National Civil Defense System and the Mexico City government. The assistance included 500 people and more than 400 tons of humanitarian aid consisting of canned food, water, basic necessities, medical supplies, field tents, electrical plants, machinery, work equipment, and tools. The presence of friends “Our friends have made themselves present during hard times, and we have been humbled to see that Mexico has true friends all over the world,” Secretary Videgaray added. “Your help can mean the difference between life and death for many people.” El Salvador was one of the first countries to arrive in Mexico. A highly trained multidisciplinary team from its Urban Search and Rescue (USAR) Group arrived in one of the Salvadoran Air Force’s Douglas C-47 turboprop planes. “Because we also live in a region that is quite seismically active, the Salvadoran Air Force has ground, air, and naval units permanently ready to provide assistance domestically and internationally,” Salvadoran Air Force General Carlos Jaime Mena Torres, the deputy minister of Defense for El Salvador, told Diálogo. “We are very proud to be the first country to arrive in Mexico in support of this contingency.” Several other nations have also joined the cause in order to provide the necessary aid. The United States, with the Los Angeles County Fire Department’s USAR team, and Japan, with a brigade made up of various corps, provided support with specialized equipment for collapsed buildings and machinery such as circular saws, high-capacity hydraulic jacks, inflatable devices for lifting debris, and geophones for searching over large swathes of terrain. Spain showed its solidarity by sending over a Military Emergency Unit contingent. And civil defense members from Israel’s Home Front Command Rescue Unit assisted with the process of reviewing the damage to buildings. This outpouring of support was aided by rescue teams from Colombia, Panama, Honduras, Ecuador, Chile, and Costa Rica, sent to locate people trapped under debris in collapsed buildings. Canada also sent rescue personnel and 1,500 field tents. In addition, several civilian businesses and associations donated financial resources to support the aid efforts for the states that were most damaged by the earthquake. “With such an outpouring of solidarity, Mexico is grateful to its brothers and sisters around the world, and it reaffirms its conviction that only by working together can we overcome the challenges that face our nation today,” the Secretariat of Foreign Relations reported. Recognition for Mexico “This international support is recognition of the way in which Mexico has extended its hand to other nations during natural disasters,” Yadira Gálvez Salvador, a security and defense issues analyst at the Autonomous National University of Mexico (UNAM per its Spanish acronym), told Diálogo. “It’s a showing of reciprocity.” Recently, Mexico assisted the United States with a group of Red Cross volunteers who worked in shelters after Hurricane Harvey passed through. Similarly, 130 rescuers and more than four tons of humanitarian aid and equipment were sent to Ecuador in April 2016, when a magnitude 7.8 earthquake struck the central part of that South American country. Challenges and strengthening “This aid allows us to measure our personnel’s level of operational readiness,” Gen. Mena remarked. “Also, [it lets us test] the capacity of our aircraft to detect any vulnerability and then go about finding solutions, whether in equipment or in training.” “This kind of humanitarian aid shows today’s challenges for international and interagency coordination during natural disasters: nations are looking to build a more effective coordination and response capacity during an emergency or a natural disaster, and they’re looking for how to create more efficiency,” Gálvez added. “The aid given to Mexico was managed in an extremely efficient way.” “The military needs to be better prepared, trained, and equipped in order to react in a positive way and help save lives,” Gen. Mena concluded. “The armed forces must get stronger because natural disasters are a constant throughout the Americas and all over the world.”last_img read more

More Than 4.6 Million Venezuelans Have Fled Their Country, OAS Reports

first_imgBy Voice of America November 01, 2019 David Smolansky, an exiled mayor and coordinator of the working group for Venezuelan migrants at the Organization of American States (OAS), presented on October 6 the latest figures on Venezuelan migrants, which, according to his calculations, have reached more than 4.6 million.Smolansky said on Twitter that among the organization’s member nations Colombia is the country where most Venezuelan migrants have arrived, with 1.6 million. The United States is third, with 422,000. The non-OAS member that received the most Venezuelans is Spain, with at least 300,000 migrants.Ecuador, which recently imposed a visa requirement on Venezuelans entering the country, is also on the list, with about 350,000 Venezuelans. Uruguay and Bolivia are the countries with the fewest Venezuelan migrants, with about 10,000 each.According to the United Nations High Commissioner for Refugees (UNHCR), the OAS figures are consistent with the latest numbers the agency issued in August, with about 4.3 million Venezuelans who have left their country in recent years.In a recent exclusive interview with Voice of America’s Venezuela 360, UNHCR High Commissioner Filippo Grandi said that more funding is needed to help the refugee crisis created by the Venezuelan exodus to more than 15 countries in the Western Hemisphere.For Smolansky, the only solution is the exit of the Nicolás Maduro regime. “The only solution to stop this unprecedented human avalanche is for the usurpation to end,” he said.last_img read more

TaxWatch: Drug courts save money

first_imgIf the Young Lawyers Division is looking for a worthwhile project, Florida TaxWatch has a suggestion: Make sure more drug courts are funded.Harvey Bennett, vice president of communications and marketing, speaking at the YLD Legislative/Governmental Symposium in Orlando, extolled the success of Florida’s drug courts, launched in the late ’80s, now serving more than 10,000 people.“There are tremendous success stories out there on drug treatment,” Bennett said. Besides helping people beat their addictions, he told of the economic benefits.“The alternative often is a jail, a prison sentence, and increased costs to local and/or state government. And drug court programs do work. They save incarceration costs of $20,000 to $50,000 per inmate annually, compared to $2,500 to $4,000 a year for drug court programs. Drug court graduates’ recidivism is at roughly half the rate of non-drug court participants (27 percent and 48 percent respectively).”Rep. Holly Benson, R-Pensacola, and chair of the House Select Committee on Article V, explained, “We support the concept.” The state will still fund existing drug court programs, she said, but the state is not going to fund additional programs. That will be an option for individual counties to fund.Citing a 1999 report by the National Institute on Drug Abuse, Bennett said, “Every dollar spent on drug court treatment programs yields a $4 to $7 savings in reduced drug-related crime, criminal justice system costs, law enforcement, prosecutions, corrections, as well as health care.”In addition, he said, there are savings from reducing inter-personal conflicts, drug-related accidents, and increasing workplace productivity.“Their discontinuation would likely increase domestic and criminal cases in the long term and correctional expenses in the short time, because those who might otherwise be diverted to alternative programs must now be incarcerated,” Bennett said.“In fact, may I suggest that if the Young Lawyers Section of The Florida Bar would be looking for a constructive way to contribute to our justice system, helping to sustain drug courts, from our research, would be a very good place to start.” TaxWatch: Drug courts save money February 15, 2004 Regular Newscenter_img TaxWatch: Drug courts save moneylast_img read more

Practice Tips–Get the address right when cutting checks

first_img May 15, 2006 Regular News Practice Tips–Get the address right when cutting checks Get the address right when cutting checks Here’s a tip for personal injury attorneys and anyone else who writes checks from a trust account on behalf of clients: Take a minute before writing each check to call the payee to confirm the proper name and address to send the check.This simple phone call will help reduce the complaints from medical providers and others claiming they were never paid; you also won’t have the hassle of reissuing a new check and stopping payment on the old check. And, since the check goes immediately to the proper address, it will help reduce the late-cashing of checks that can put a glitch in your trust account reconciliation process. Practice Tips is a service of the Practice Management Advisors Committee of the ABA Law Practice Management Section. It is not intended as legal advice, nor is it an authorized legal ethics opinion binding on any state bar or law society. For additional information about PMA services in Florida contact The Florida Bar’s Law Office Management Assistance Service (LOMAS) at (866) 730-2020.last_img read more

North Merrick Crash Leaves 1 Dead

first_imgSign up for our COVID-19 newsletter to stay up-to-date on the latest coronavirus news throughout New York A driver was killed and four passengers were wounded in an SUV crash on the Southern State Parkway in North Merrick early Monday morning.New York State police said the truck was being driven eastbound when the driver lost control near exit 24 and hit the guiderail, causing the SUV to roll over down an embankment at 4:29 a.m.All five occupants were taken to local hospitals. One is listed in critical condition.Police are continuing the investigation into the cause of the crash. The victims’ identities were not immediately available.last_img