zoom Athens-based drybulk shipping firm DryShips Inc. has determined to effect a 1-for-4 reverse stock split of the company’s common shares. At the company’s annual general meeting of shareholders on October 26, 2016, the shareholders approved the reverse stock split and granted the Board of directors, or a duly constituted committee thereof, the authority to determine the exact split ratio and proceed with the reverse stock split.The reverse stock split will take effect, and the company’s common stock will begin trading on a split adjusted basis on the Nasdaq Capital Market as of the opening of trading on April 11, 2017, DryShips said.When the reverse stock split becomes effective, every four shares of the company’s issued common stock will be automatically combined into one share of common stock.DryShips added that no fractional shares will be issued in connection with the reverse split of the issued common stock.For the full year 2016, DryShips’ net loss stood at USD 198.6 million, compared to a net loss of USD 2.8 billion seen in 2015. For the fourth quarter of 2016, the firm posted a net loss of USD 77.5 million, against USD 527.6 million loss recorded in the same period of 2015.Revenue for the full-year period was USD 51.9 million, compared to USD 969.8 million posted in 2015. Additionally, revenue for the last quarter of 2016 amounted to USD 12.8 million, against USD 23.7 million.
Making it fairThose kinds of prices make Ayodele Williams, 44, of Philadelphia, outraged. She and her sister were in New York last week to see a performance of Hamilton, and they had tickets they consider themselves lucky to have snagged at face value last fall.“It’s become so expensive and rigged,” Williams said. “If you have some kind of system or algorithm that allows you to buy all these tickets, you’re going to get them and then all you’re doing is re-selling. You’re not doing it for the love of the show really. You’re doing it for the love of the money.”David Marcus, executive vice-president for Ticketmaster, said that was the point of the registration system: to give fans a better experience.“It’s intended to make the initial distribution fairer,” he said, to fight against a system where brokers are the first ones out of the gate for tickets.Re-sale has a role, he said, but it shouldn’t be the oversize one it’s playing.He said so far the program has been working. Of the more than a million tickets distributed through Verified Fan since it began beta testing late last year, less than 5 per cent have gone onto the secondary re-sale market. Getting more useVerified Fan has been used for concert sales for artists such as Ed Sheeran and Harry Styles, and is now showing up for Broadway sales. Springsteen on Broadway, running from Oct. 3 to Nov. 26, is using the system, as is another show expected to be a hot prospect, Harry Potter and the Cursed Child, opening next spring.The producers of the immensely popular Hamilton announced Tuesday that a new block of tickets for the show would go on sale through Verified Fan. That show has been the subject of a huge re-sale market, with tickets going for hundreds of dollars if not more than the face values.Premium seats for Hamilton run as high as $849 US, with prices on the secondary ticket markets more than double that amount. While Hamilton has put aside a few digital lottery seats for $10, the average ticket last week went for $282.65.A theatre goer purchases a ticket to the Broadway show Hamilton in New York. The incredibly popular show announced this week that it would be the latest to offer up a new block of tickets for sale using Verified Fan. (Richard Drew/The Associated Press) Advertisement Advertisement The registrations are reviewed, including past ticket purchase history and even social media accounts, with an eye toward determining whether they’re more likely to be event attendees.Those accepted get unique codes that they can use when they go to buy tickets on the sale date.The premise is that by vetting registrants, it’s more likely that actual fans would be the ones getting the first crack at hot tickets, instead of brokers and re-sellers.“That makes me feel better,” said Elster, 66, a videographer who lives in Margate, Florida. “That makes me feel like I have a chance maybe, more of a chance than usual.”Tickets for Springsteen’s show go on sale Aug. 30.Tickets for Bruce Springsteen’s upcoming Broadway show, featuring songs from his career interspersed with readings from his memoir, will be sold using Verified Fan. (Matt Slocum/The Associated Press) LEAVE A REPLY Cancel replyLog in to leave a comment Login/Register With: Facebook A program from Ticketmaster called Verified fan is trying to put more Broadway tickets in the hands of fans rather than re-sale outlets. (Paul Sakuma/The Associated Press) For longtime Bruce Springsteen fan Debbie Elster, there’s never been any doubt the competition to get tickets for his upcoming Broadway shows is going to be fierce.But she’s feeling a little more hopeful, thanks to a new online verification system for ticket-buying that aims to keep more tickets in the hands of fans rather than re-sellers who seemingly snap them up and put them on the market, often for several times the face value.Known as Verified Fan, the program from Ticketmaster requires people to register for a specific sale in advance, with information including their names, phone numbers and emails.Identities verified Advertisement Twitter
APTN National NewsAPTN broadcast a video from Iqaluit Wednesday showing an RCMP officer hitting a man in custody.APTN received the video because the man who was hit wanted the public to see it.APTN’s Kent Driscoll has more on this story.
Posted: November 13, 2018 Sasha Foo, November 13, 2018 00:00 00:00 spaceplay / pause qunload | stop ffullscreenshift + ←→slower / faster ↑↓volume mmute ←→seek . seek to previous 12… 6 seek to 10%, 20% … 60% XColor SettingsAaAaAaAaTextBackgroundOpacity SettingsTextOpaqueSemi-TransparentBackgroundSemi-TransparentOpaqueTransparentFont SettingsSize||TypeSerif MonospaceSerifSans Serif MonospaceSans SerifCasualCursiveSmallCapsResetSave SettingsALPINE (KUSI) – An investigation is underway into the deputy involved shooting of a 30 year old Alpine man. Danny Ayala was shot to death by deputies who answered a call Monday afternoon at the Summit at Alpine apartment homes. Someone at the apartment complex called 911 just before 3 p.m. to report a man who was yelling death threats. When deputies arrived, they said Ayala who was holding a knife began to advance towards them. According to homicide investigators, the deputies who feared for their lives, fired multiple shots at Ayala outside his apartment. The deputies administered first aid and CPR but Ayala died at the scene.However, Ayala’s family said it had heard a different version of the events from witnesses who claimed he was shot multiple times inside the apartment, after deputies broke through the door. Juan Ruiz, the victim’s uncle also questioned the treatment of Ayala’s four year old son, who may have witnessed the shooting and was taken into the the custody of the Sheriff’s Department after the shooting. Family members also said they were not informed about the child’s whereabouts for hours.“They should have called somebody as protocol, called somebody to “come pick up your child.’ You don’t just take a child and don’t tell nobody. You know, everybody was looking for the kid and nobody knows where he’s at,” Ruiz said. Family members said they were not notified of Ayala’s death by law enforcement, but learned of his death through the news media.At this time, no one is sure what happened in the moments before deputies opened fire. Homicide investigators were not able to say what deputies said to Ayala before the shooting. Vanessa Moore, Ayala’s cousin said the family wants more answers from the Sheriff’s Department. “People get upset all the time- unless there was a gun out there, unless he pointed a gun at the officers, which is not what they say happened- he had a knife, why did they tear down his door?”All these things that the policemen say happened and didn’t happen? We just need answers and if they don’t have them, that’s a little suspect to us, right now,” Moore said. Sasha Foo Updated: 10:02 AM Alpine man fatally shot, after allegedly charging sheriff deputies with a knife Categories: Local San Diego News FacebookTwitter
More information: Hyowon Seo et al. Photoredox activation of carbon dioxide for amino acid synthesis in continuous flow, Nature Chemistry (2016). DOI: 10.1038/nchem.2690AbstractAlthough carbon dioxide (CO2) is highly abundant, its low reactivity has limited its use in chemical synthesis. In particular, methods for carbon–carbon bond formation generally rely on two-electron mechanisms for CO2 activation and require highly activated reaction partners. Alternatively, radical pathways accessed via photoredox catalysis could provide new reactivity under milder conditions. Here we demonstrate the direct coupling of CO2 and amines via the single-electron reduction of CO2 for the photoredox-catalysed continuous flow synthesis of α-amino acids. By leveraging the advantages of utilizing gases and photochemistry in flow, a commercially available organic photoredox catalyst effects the selective α-carboxylation of amines that bear various functional groups and heterocycles. The preliminary mechanistic studies support CO2 activation and carbon–carbon bond formation via single-electron pathways, and we expect that this strategy will inspire new perspectives on using this feedstock chemical in organic synthesis. Design plan for α-carboxylation of amines with CO2. a, Carbon–carbon bond formation with CO2 has generally relied on two-electron reaction pathways with an extended π system or a strong nucleophile. Cat., catalyst. b, Single-electron reduction of carbon dioxide and its reaction with an α-amino radical to provide an α-amino acid. c, Continuous flow setup for the photoredox-catalysed synthesis of α-amino acids. The reactants were introduced via a gas-tight syringe that contained a solution of the amine substrate, base and catalyst. CO2 gas was metered into the system by a mass flow controller (MFC). These two streams were joined by a T-mixer before irradiation under an ultraviolet lamp. The pressure of CO2 is controlled by a back-pressure regulator (BPR). Credit: (c) Nature Chemistry (2016). DOI: 10.1038/nchem.2690 Hyowon Seo, Matthew H. Katcher, and Timothy F. Jamison of Massachusetts Institute of Technology have developed a continuous flow system that allows for the single-electron reduction of CO2 that combines with a variety of amines to form α-amino acids. Their methodology involves the use of a photoredox catalyst and, using their flow system, optimized reaction conditions to obtain regioselective α-amino acids in high yields. Their work appears in Nature Chemistry.The keys to this group’s procedure are the photoredox catalyst and the ability to fine-tune their reaction conditions using their continuous flow system. In determining the appropriate photoredox catalyst, Seo et al. tested para-terphenyl based on prior work by Yanagida’s group. This catalyst was attractive because it has an appropriately high reduction potential to reduce CO2.The photoredox catalyst served to remove an electron from the amine as well as to catalyze the reduction of CO2. These two radical molecules then combined to form a C-C bond at the benzylic C-H of an N-benzyl compound resulting in an α-amino acid. Additional experiments showed that this reaction worked well with a variety of amines including those that do not have a benzylic carbon.The second important aspect to this reaction mechanism is the continuous flow set up. Carbon dioxide gas is mixed with a liquid aspiration of amine and catalyst. This system allowed for the controlled flow of CO2, which in turn allowed for the controlled combination of the amine radical and the CO2 radical. Seo et al. were able to optimize the pressure and flow of CO2 to obtain maximum yields. An additional advantage to this set up was the short path length of light, which also helped control when it would activate the catalyst and prompt the redox reaction to occur.Using N-benzylpiperdine as their model reaction, Seo et al. tested their apparatus first using the reaction conditions reported by Yanagida’s group. They then optimized the conditions to eventually obtain the desired α-amino acid in 92% yield. Among their changes, they added potassium trifluoroacetate (KOCOCF3) base, which helped with yields and regioselectivity. While mechanistic studies did not reveal exactly how the base is used, Seo et al. hypothesized that it served as a salt stabilizer.Additionally, Seo et al. optimized their reaction using a UV filter. This prohibited the formation of unwanted by-products that resulted from short wave irradiation. In do this, they obtained 92% yield of the desired α-amino acid. Prior to using the UV filter, they would obtain two different regio isomers, but after the filter, they saw almost exclusive regioselectivity for the desired product (i.e., carboxylation at the benzylic position).Once they obtained the optimal reaction conditions, they then tried to make a variety of α-amino acids. Notably, all cases showed a greater than 20-to-1 regioselectivity in favor of the desired α-amino acid. Among their results, they found that N-benzylpiperdines with ortho-, meta-, and para-alkyl substitution worked well, resulting in the desired α-amino acids as did chloroarenes and a variety of amines. Amines with several types of heterocycles and fused rings tolerated the reaction conditions well. N-benzyl amines with electron poor arenes did not do as well, and neither did alcohols, ketals, or primary amines. However, masked versions of alcohols and ketals can be produced, and the reaction does tolerate 4-piperidone analogs as a possible bis-protecting group for primary amines. Also their reaction worked well when tested on a known pharmaceutical ingredient with a heterocycle and no benzylic C-H bond (ticlopidine).”Very interesting to us is the fundamental chemistry of the radical anion of carbon dioxide, which we’ve proposed as a key intermediate in this process,” says Professor Timothy Jamison. “Some of our ongoing efforts are directed toward using this enabling platform as a means toward this aim.” Citation: Amino acids formed from the single-electron activation of carbon dioxide (2017, January 12) retrieved 18 August 2019 from https://phys.org/news/2017-01-amino-acids-single-electron-carbon-dioxide.html (Phys.org)—Carbon dioxide, an abundant greenhouse gas, is very difficult to use as a carbon source for carbon-carbon bond formation. CO2 is highly stable and unreactive, requiring prohibitively difficult or toxic reagents in order to form carbon bonds. Regioselective hydroarylation of alkynes to make ortho-, para-, and meta- products Journal information: Nature Chemistry Explore further This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only. © 2017 Phys.org